GABA pathways involve virtually all parts of the brain and exert a calming influence
in all of these regions (CNSforum, 2005).

GABA in Methamphetamine Dependence
GABAergic systems are involved in multiple aspects of dependence and withdrawal. Most of the addictive effects of meth are thought to result from its binding to GABA receptors and amplifying the naturally calming effect that GABAergic neurotransmission has on the brain, mood, and behavior (NIAAA, 2003). 

GABAergic systems are also involved in maintaining addiction to meth.  Methamphetamine abuse is maintained by much more than the rewards they provide. In fact, avoiding the negative consequences of stopping use of these agents may, over time, become much more important than reward. GABA plays a key role in these processes that contribute to maintained meth abuse (Koob, 2004; Backes, 2003).